{"id":81,"date":"2026-05-05T12:33:56","date_gmt":"2026-05-05T11:33:56","guid":{"rendered":"https:\/\/idcc.usm.md\/?page_id=81"},"modified":"2026-10-19T07:10:03","modified_gmt":"2026-10-19T06:10:03","slug":"laboratorul-materiale-avansate-in-biofarmaceutica","status":"publish","type":"page","link":"https:\/\/idcc.usm.md\/?page_id=81","title":{"rendered":"Laboratorul Materiale Avansate \u00een Biofarmaceutic\u0103 \u0219i Tehnic\u0103"},"content":{"rendered":"
\n
\n\n\n\n
\u0218eful laboratorului
\nacademician, dr. habilitat, prof. univ.\u00a0Aurelian GULEA<\/strong><\/p>\n\n\n\n\n\n
Birou:<\/td>\n<\/td>\n<\/tr>\n
Telefon:<\/td>\n<\/td>\n<\/tr>\n
Email:<\/td>\naurelian.gulea @ usm.md<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n\"poza<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
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Domenii de cercetare<\/strong><\/div>\n
\n

Direc\u021biile actuale de cercetare ale laboratorului\u00a0sunt orientate spre biomedicin\u0103 \u0219i materiale avansate\/inovative.
\nActivitatea principal\u0103 se concentreaz\u0103 pe designul, sinteza dirijat\u0103 \u0219i caracterizarea de noi combina\u021bii coordinative (ale biometalelor) cu liganzi polifunc\u021bionali care con\u021bin seturi de atomi NNS, SNO, etc., av\u00e2nd ca scop ob\u021binerea de inhibitori moleculari ai prolifer\u0103rii celulelor canceroase \u0219i agen\u021bi cu propriet\u0103\u021bi antimicrobiene sau antimicotice.
\nDe asemenea, laboratorul investigheaz\u0103 asamblarea materialelor func\u021bionale \u0219i a sistemelor supramoleculare cu aplicabilitate practic\u0103 at\u00e2t \u00een sectorul biofarmaceutic.<\/p>\n

Componen\u021ba<\/span>Publica\u021bii recente<\/span>Proiecte de cercetare<\/span>Nout\u0103\u021bi<\/span><\/div>
\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Aurelian GULEA<\/a>
\nAcademician, doctor habilitat, profesor universitar
\n\u0218ef laborator<\/td>\n		<\/td>\n<\/tr>\n
Vasilii\u00a0GRAUR<\/a>
\nDocotor, cercet\u0103tor \u0219tiin\u021bific coordonator<\/td>\n		<\/td>\n<\/tr>\n
Roman RUSNAC<\/a>
\nDoctor, cercet\u0103tor \u0219tiin\u021bific superior<\/td>\n		<\/td>\n<\/tr>\n
Irina USATAIA (KRAVCIUK)
\nDoctor, cercet\u0103tor \u0219tiin\u021bific superior<\/td>\n		<\/td>\n<\/tr>\n
Ianina GRAUR
\nDoctor, cercet\u0103tor \u0219tiin\u021bific superior<\/td>\n		<\/td>\n<\/tr>\n
Victor<\/a>\u00a0\u021aAPCOV<\/a>
\nDoctor, cercet\u0103tor \u0219tiin\u021bific coordonator<\/td>\n		<\/td>\n<\/tr>\n
Olga GARBUZ
\nDoctor, cercet\u0103tor \u0219tiin\u021bific superior<\/td>\n		<\/td>\n<\/tr>\n
Angela S\u00ceRBU
\nDoctor, cercet\u0103tor \u0219tiin\u021bific superior<\/td>\n		<\/td>\n<\/tr>\n
Ion BULIMESTRU<\/a>
\nDoctor, cercet\u0103tor \u0219tiin\u021bific superior<\/td>\n		<\/td>\n<\/tr>\n
Maria B\u00ceRC\u0102
\nDoctor, cercet\u0103tor \u0219tiin\u021bific superior<\/td>\n		<\/td>\n<\/tr>\n
Nelea POPA
\nDoctor, cercet\u0103tor \u0219tiin\u021bific superior<\/td>\n		<\/td>\n<\/tr>\n
Aliona COTOVAIA
\nDoctor, cercet\u0103tor \u0219tiin\u021bific superior<\/td>\n		<\/td>\n<\/tr>\n
Aliona P\u00ceNTEA
\nCercet\u0103tor \u0219tiin\u021bific stagiar<\/td>\n		<\/td>\n<\/tr>\n
Elena TUTOVAN
\nDoctor, cercet\u0103tor \u0219tiin\u021bific<\/td>\n		<\/td>\n<\/tr>\n
Andrei CIURSIN
\nLaborant superior<\/td>\n		<\/td>\n<\/tr>\n
Iulia GRIBANOVA
\nLaborant superior<\/td>\n		<\/td>\n<\/tr>\n
Valentina PLE\u0218CA
\nLaborant superior<\/td>\n		<\/td>\n<\/tr>\n
Nadejda RAILEAN
\nInginer<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

Monografii (sau capitole \u00een monografii) din \u021bar\u0103, recomandate de Consiliul \u0219tiin\u021bific al USM\/al institutului \u00a0\u00a0<\/strong><\/p>\n

    \n
  1. GARBUZ, O., TODERAS, I., GULEA, A. (ICh al USM). Biological properties of some synthetic and natural compounds. Correlation of anticancer and antioxidant activities. Monograph. Tipografia Central\u0103. 271 p. Chisinau, 2024. ISBN 978-5-88554-387-3. https:\/\/zoology.usm.md\/sites\/default\/files\/2025-01\/Garbuz%20et%20al_2024_contents.pdf<\/a><\/li>\n
  2. GRAUR, V. (ICh al USM), GULEA, A. (ICh al USM). Novel biological agents based on metal complexes of N4-allylthiosemicarbazones and their derivatives. Monograph. Chi\u0219in\u0103u: CEP USM, 2024, 290 p. ISBN 978-9975-62-716-0.<\/li>\n<\/ol>\n

    Articole \u00een reviste indexate \u00een\u00a0 bazele de date Web of Science \u0219i\/sau Scopus de categoria Q1<\/strong><\/p>\n

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    1. CEBOTARI, D., ALCHAMANDI, R., MOLARD, Y., AMELA\u2010CORTES, M., LIVAGE, C., HAOUAS, M., MARROT, J., GULEA, A., GORNY, C., FAYOLLE, B., CALANCEA, S., FLOQUET, S. Embedding Mo2O2S2\u2010Bis (thiosemicarbazone) Complexes Into Polyurethane Matrices: Synthesis and Characterization. In: Journal of Polymer Science, 2025, 63(8), 1760-1773. https:\/\/doi.org\/10.1002\/pol.20240556<\/a>, https:\/\/www.scimagojr.com\/journalsearch.php?q=21101023153&tip=sid<\/a><\/li>\n
    2. FUIOR, A., COLIN-DUCHEVET, L., CEBOTARI, V., NO\u00cbL, A., RIBAUD, I., G\u00c9RARD, I., GARBUZ, O., FREGNAUX, M., L\u00d3PEZ, X., LARCHER, V., SHESTOPALOV, M., SOLOVIEVA, A., POZMOGOVA, T., GLIGA, O., RAILEAN, N., COCHARD, P., POIROT, B., CHARISTOS, L., HATJINA, F., SOMOGYI, A., MEDJOUBI, K., GAUMER, S., GULEA, A., TODERAS, I., SANDOZ, J., FLOQUET, S. Feed supplementation with molybdenum complexes improves honey bee health. In: Inorganic Chemistry Frontiers, 2025, 12(22), 7107-7122. https:\/\/doi.org\/10.1039\/D5QI00878F<\/a>, https:\/\/www.scimagojr.com\/journalsearch.php?q=21100403917&tip=sid<\/a><\/li>\n
    3. GARBUZ, O., CEBAN, E., ISTRATI, D., RAILEAN, N., TODERAS, I., GULEA, A. Thiosemicarbazone-Based Compounds: Cancer Cell Inhibitors with Antioxidant Properties. In: Molecules,<\/i> 2025, 30(9), 2077. <\/span>https:\/\/doi.org\/10.3390\/molecules30092077<\/span><\/a>, <\/span>https:\/\/www.scimagojr.com\/journalsearch.php?q=26370&tip=sid<\/span><\/a><\/li>\n
    4. RUSNAC, Roman (ICh al USM), GARBUZ, Olga, KRAVTSOV, Victor, MELNIC, Elena, ISTRATI, Dorin, TSAPKOV, Victor, POIRIER, Donald, GULEA, Aurelian (ICh al USM). Novel Copper(II) Coordination Compounds Containing Pyridine Derivatives of N4-methoxyphenyl-Thiosemicarbazones with Selective Anticancer Activity. In: Molecules, 2024, vol. 29, nr. 24, pag. 60022024. https:\/\/doi.org\/10.3390\/molecules29246002<\/a>, https:\/\/scholar.google.com\/citations?view_op=view_citation&hl=ro&user=ONi_tMIAAAAJ&sortby=pubdate&citation_for_view=ONi_tMIAAAAJ:SjuI4pbJlxcC<\/a> \u00a0\u00a0https:\/\/www.scimagojr.com\/journalsearch.php?q=26370&tip=sid<\/a><\/li>\n
    5. GRAUR, I. (ICh al USM), GRAUR, V. (ICh al USM), CADIN, M., GARBUZ, O., BOUROSH, P., MELNIC, E., LOZAN-TIRSU, C., BALAN, G., TSAPKOV, V., FALA, V., GULEA, A. (ICh al USM). Synthesis and Characterization of Copper(II) and Nickel(II) Complexes with 3-(Morpholin-4-yl)propane-2,3-dione 4-Allylthiosemicarbazone Exploring the Antibacterial, Antifungal and Antiradical Properties. In: Molecules, 2024, 29(16), 3903. https:\/\/doi.org\/10.3390\/molecules29163903<\/a>. https:\/\/www.scimagojr.com\/journalsearch.php?q=26370&tip=sid<\/a><\/li>\n
    6. CEBOTARI, D., CALANCEA, S., MARROT, J., GUILLOT, R., FALAISE, C., GU\u00c9RINEAU, V., TOUBOUL, D., HAOUAS, M., GULEA, A. (Facultatea de Chimie \u0219i Tehnologie Chimic\u0103 \u0219i Tehnologie Chimic\u0103 a USM), \u00a0FLOQUET, S, Tuning the nuclearity of [Mo2O2S2]2+-based assemblies by playing with the degree of flexibility of bis-thiosemicarbazone ligands. In: Dalton Transactions, 2023, vol. 52(10), 3059-3071. DOI: https:\/\/doi.org\/10,1039\/d2dt03760b<\/a> (IF: 3,5). https:\/\/www.scimagojr.com\/journalsearch.php?q=9500153949&tip=sid&clean=0<\/a><\/li>\n<\/ol>\n

      Articole \u00een reviste indexate \u00een\u00a0 bazele de date Web of Science \u0219i\/sau Scopus de categoria Q2<\/strong><\/p>\n

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      1. GRAUR, V., GRAUR, I., BOUROSH, P., KRAVTSOV, V., LOZAN-TIRSU, C., BALAN, G., GARBUZ, O., TSAPKOV, V., GULEA, A. Synthesis, Characterization, and Biological Evaluation of Some 3d Metal Complexes with 2-Benzoylpyridine 4-Allylthiosemicarbazone. In: Inorganics, 2025, 13(7), 249-268. https:\/\/doi.org\/10.3390\/inorganics13070249<\/a>, https:\/\/www.scimagojr.com\/journalsearch.php?q=21100857210&tip=sid<\/li>\n
      2. BUILS, J., CALANCEA, S., BOUAOUNI, Y., ALCHAMANDI, R., LAURANS, M., CEBOTARI, D., MARROT, J., FR\u00c9GNAUX, M., GULEA, A., SEGADO-CENTELLAS, M., CARLES, B., FLOQUET, S. Hydrogen evolution reaction evidenced for Mo2O2S2-thiosemicarbazone coordination complexes. In: Dalton Transactions, 2025, 54(26), 10381-10395. https:\/\/doi.org\/10.1039\/D5DT00399G<\/a>, https:\/\/www.scimagojr.com\/journalsearch.php?q=9500153949&tip=sid<\/li>\n
      3. CEBOTARI, D., CALANCEA, S., GARBUZ, O., BALAN, G., MARROT, J., SHOVA, S., GU\u00c9RINEAU, V., TOUBOUL, D., TSAPKOV, V., GULEA, A. (ICh al USM), FLOQUET, S. Synthesis, structure and biological properties of a series of dicopper (bis-thiosemicarbazone) complexes. In: New Journal of Chemistry, 2024, 48(26), 12043-12053. https:\/\/doi.org\/10.1039\/D4NJ003s42J<\/a> https:\/\/www.scimagojr.com\/journalsearch.php?q=24824&tip=sid<\/a><\/li>\n
      4. CEBOTARI, D., BUILS, J., GARBUZ, O., BALAN, G., MARROT, J., GU\u00c9RINEAU, V., TOUBOUL, D., HAOUAS, M., SEGADO-CENTELLES, M., BO, C., GULEA, A. (Facultatea de Chimie \u0219i Tehnologie Chimic\u0103 \u0219i Tehnologie Chimic\u0103 a USM), \u00a0FLOQUET, S. A new series of bioactive Mo(V)2O2S2-based thiosemicarbazone complexes: Solution and DFT studies, and antifungal and antioxidant activities, In: Journal of Inorganic Biochemistry, 2023, vol. 245, 112258. DOI: https:\/\/doi.org\/10.1016\/j.jinorgbio.2023.112258<\/a>. https:\/\/www.scimagojr.com\/journalsearch.php?q=17615&tip=sid&clean=0<\/a><\/li>\n
      5. FUIOR, A., CEBOTARI, D., GARBUZ, O. (Facultatea de Chimie \u0219i Tehnologie Chimic\u0103 \u0219i tehnologie Chimic\u0103 a USM), CALANCEA, S., GULEA, A, (Facultatea de Chimie \u0219i Tehnologie Chimic\u0103 \u0219i Tehnologie Chimic\u0103 a USM), FLOQUET, S, Biological properties of a new class of [Mo2O2S2]-based thiosemicarbazone coordination complexes. In: Inorganica Chimica Acta 2023, vol, 548, 121372. DOI: https:\/\/doi.org\/10.1016\/j.ica.2022.121372<\/a>, https:\/\/www.scimagojr.com\/journalsearch.php?tip=sid&q=25270<\/a> (Domeniul articolului: Inorganic Chemistry)<\/li>\n
      6. GRAUR, V. (Facultatea de Chimie \u0219i Tehnologie Chimic\u0103 \u0219i Tehnologie Chimic\u0103 a USM), USATAIA, I. (Facultatea de Chimie \u0219i Tehnologie Chimic\u0103 \u0219i Tehnologie Chimic\u0103 a USM), \u00a0GRAUR, I. (Facultatea de Chimie \u0219i Tehnologie Chimic\u0103 \u0219i Tehnologie Chimic\u0103 a USM), \u00a0GARBUZ, O. (Facultatea de Chimie \u0219i Tehnologie Chimic\u0103 \u0219i tehnologie Chimic\u0103 a USM),\u00a0 BOUROSH, P., KRAVTSOV, V., LOZAN-TIRSU, C., BALAN, G., FALA, V., GULEA, A. (Facultatea de Chimie \u0219i Tehnologie Chimic\u0103 \u0219i Tehnologie Chimic\u0103 a USM), Novel Copper(II) Complexes with\u00a0N4,S-Diallylisothiosemicarbazones as Potential Antibacterial\/Anticancer Drugs, In: Inorganics, 2023; vol. 11(5), 195, https:\/\/doi.org\/10.3390\/inorganics11050195<\/a>. https:\/\/www.scimagojr.com\/journalsearch.php?q=21100857210&tip=sid&clean=0<\/a><\/li>\n
      7. RUSNAC, R. (Facultatea de Chimie \u0219i Tehnologie Chimic\u0103 \u0219i Tehnologie Chimic\u0103 a USM), \u00a0GARBUZ, O. (Facultatea de Chimie \u0219i Tehnologie Chimic\u0103 \u0219i tehnologie Chimic\u0103 a USM), CHUMAKOV, Y., TSAPKOV, V. (Facultatea de Chimie \u0219i Tehnologie Chimic\u0103 \u0219i Tehnologie Chimic\u0103 a USM)., HUREAU, C., ISTRATI, D., GULEA, A. (Facultatea de Chimie \u0219i Tehnologie Chimic\u0103 \u0219i Tehnologie Chimic\u0103 a USM), Synthesis, Characterization, and Biological Properties of the Copper (II) Complexes with Novel Ligand: N-[4-({2-[1-(pyridin-2-yl) ethylidene] hydrazinecarbothioyl} amino) phenyl] acetamide. In: Inorganics, 2023, Vol, 11(10), 408. DOI: https:\/\/doi.org\/10.3390\/inorganics11100408<\/a>, https:\/\/www.scimagojr.com\/journalsearch.php?q=21100857210&tip=sid&clean=0<\/a><\/li>\n<\/ol>\n

        Articole \u00een reviste indexate \u00een \u00a0bazele de date Web of Science \u0219i\/sau Scopus de categoria Q3<\/strong><\/p>\n

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        1. CHUMAKOV, Y., GRAUR, V. (ICh al USM), GRAUR, I. (ICh al USM), TSAPKOV, V., GARBUZ, O., GULEA, A. (ICh al USM). Insights into Antiradical Behavior: Crystal Structures and DFT Analysis of 2-Formylpyridine N4-Allylthiosemicarbazone Salts. In: Acta Chimica Slovenica. 2024, 71, 609-618. ISSN 1318-0207. https:\/\/doi.org\/10.17344\/acsi.2024.8728<\/a>\u00a0 https:\/\/www.scimagojr.com\/journalsearch.php?q=22658&tip=sid&clean=0<\/a><\/li>\n
        2. GRAUR, V. (Facultatea de Chimie \u0219i Tehnologie Chimic\u0103 \u0219i Tehnologie Chimic\u0103 a USM), \u00a0MARDARI, A., BOUROSH, P., KRAVTSOV, V., USATAIA, I. (Facultatea de Chimie \u0219i Tehnologie Chimic\u0103 \u0219i Tehnologie Chimic\u0103 a USM), ULCHINA, I. (Facultatea de Chimie \u0219i Tehnologie Chimic\u0103 \u0219i Tehnologie Chimic\u0103 a USM), GARBUZ, O. (Facultatea de Chimie \u0219i Tehnologie Chimic\u0103 \u0219i tehnologie Chimic\u0103 a USM), GULEA, A. (Facultatea de Chimie \u0219i Tehnologie Chimic\u0103 \u0219i Tehnologie Chimic\u0103 a USM)., Novel Antioxidants Based on Selected 3d Metal Coordination Compounds with 2-Hydroxybenzaldehyde 4,S-Diallylisothiosemicarbazone. In: Acta chimica Slovenica, 2023, vol. 70, pp. 122-130. ISSN 1318-0207. DOI: https:\/\/doi.org\/10.17344\/acsi.2022.7885<\/a>. https:\/\/www.scimagojr.com\/journalsearch.php?q=22658&tip=sid&clean=0<\/a><\/li>\n<\/ol>\n

          Articole \u00een reviste indexate \u00een \u00a0bazele de date Web of Science \u0219i\/sau Scopus de categoria Q4<\/strong><\/p>\n

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          1. CIURSIN, Andrei; RUSNAC, Roman; GULYA, Aurelian. Synthesis, absorption, distribution, metabolism, excretion and antioxidant assay of some N4 \u2013 substituted Thiosemicarbazones of Cinnamaldehyde. In: One Health and Risk Management, 2025, nr. 3, pp. 54-65. ISSN 2587-3458.https:\/\/doi.org\/10.38045\/ohrm.2025.3.05<\/a>, https:\/\/www.scimagojr.com\/journalsearch.php?q=21101180568&tip=sid&clean=0<\/li>\n
          2. USATAIA, I., GRAUR, V., BOUROSH, P., MELNIC, E., BALAN, G., LOZAN-TIRSU, C., GARBUZ, O., GULEA, A. Synthesis, Structure, and Biological Activity of New Coordination Compounds of Selected 3d-Metals with 4,S-Diallylisothiosemicarbazones of 2-Formyl-and 2-Acetylpyridine. In: Russian Journal of General Chemistry, 2025, 95(9), 2390-2401. https:\/\/doi.org\/10.1134\/S1070363225604521<\/a>, https:\/\/www.scimagojr.com\/journalsearch.php?q=21525&tip=sid<\/li>\n
          3. GRAUR, V. (ICh al USM), GRAUR, I. (ICh al USM), BOUROSH, Pavlina, BALAN, Greta, GARBUZ, Olga, TSAPKOV, Victor I., GULEA, A. (ICh al USM). Synthesis, Structure, and Biological Activity of Mixed-Ligand Copper(II) Coordination Compounds with 2-(3,5-Dibromo-2-hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide Containing Certain N-Heteroaromatic Bases. In: Russian Journal of General Chemistry, 2024, vol. 94, pp. 3252-3262. https:\/\/doi.org\/10.1134\/S1070363224120168<\/a>
            \n            https:\/\/link.springer.com\/content\/pdf\/10.1134\/S1070363224120168.pdf<\/a><\/li>\n
          4. GRAUR, I. (Facultatea de Chimie \u0219i Tehnologie Chimic\u0103 \u0219i Tehnologie Chimic\u0103 a USM), \u00a0BESPALOVA, T., GRAUR, V. (Facultatea de Chimie \u0219i Tehnologie Chimic\u0103 \u0219i Tehnologie Chimic\u0103 a USM), TSAPCOV, V. (Facultatea de Chimie \u0219i Tehnologie Chimic\u0103 \u0219i Tehnologie Chimic\u0103 a USM), GARBUZ, O. (Facultatea de Chimie \u0219i Tehnologie Chimic\u0103 \u0219i Tehnologie Chimic\u0103 a USM), MELNIC, E., BOUROSH, P., GULEA, A. (Facultatea de Chimie \u0219i Tehnologie Chimic\u0103 \u0219i Tehnologie Chimic\u0103 a USM), A new thiosemicarbazone and its 3d metal complexes: Synthetic, structural, and antioxidant studies, In: Journal of Chemical Research, 2023, vol, 47(6). DOI:10.1177\/17475198231216422<\/a>, (IF: 1,0) https:\/\/www.scimagojr.com\/journalsearch.php?q=19700184900&tip=sid<\/a><\/li>\n
          5. PANTEA, V., ANDRONACHE, L., GLOBA, P., PAVLOVSCHI, E., GULEA, A. (Facultatea de Chimie \u0219i Tehnologie Chimic\u0103 \u0219i Tehnologie Chimic\u0103 a USM), TAGADIUC, O., GUDUMAK, V, Copper coordination compounds with thiosemicarbazones: in vitro assessment of their potential in inhibiting glioma viability and proliferation.\u00a0In:\u00a0Archives of the Balkan Medical Union, 2023, vol. 58, pp. 234-244. ISSN 1584-9244, DOI: https:\/\/doi.org\/10.31688\/ABMU.2023.58.3.02<\/a>, https:\/\/www.scimagojr.com\/journalsearch.php?q=100850&tip=sid<\/a><\/li>\n<\/ol>\n

            Brevete de inven\u021bie interna\u021bionale<\/strong><\/p>\n

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            1. Arcadie FUIOR, S\u00e9bastien FLOQUET, Valentina CEBOTARI, Diana CEBOTARI, Aurelian GULEA (USM), Ion TODERAS.\u00a0Molybdenum-based feed supplement for bees. PL4185594T3, Poland.\u00a0Polish translation of the European patent.\u00a0https:\/\/patents.google.com\/patent\/PL4185594T3\/en?inventor=S\u00e9bastien+FLOQUET<\/a><\/li>\n
            2. FUIOR Arcadie,\u00a0 FLOQUET S\u00e9bastien, CEBOTARI Valentina, CEBOTARI Diana, GULEA Aurelian,\u00a0TODERAS IonFood supplement based on molybdenum for bees. Brevet de inven\u021bie Francez FR3112667A1. Data public\u0103ri 2024-02-23.\u00a0https:\/\/patents.google.com\/patent\/FR3112667A1\/en?oq=+FR3112667A1<\/a>.\u00a0\u00a0https:\/\/worldwide.espacenet.com\/patent\/search?q=pn%3DFR3112667A1<\/a><\/li>\n
            3. FUIOR Arcadie,\u00a0FLOQUET S\u00e9bastien, CEBOTARI Valentina, CEBOTARI Diana, GULEA Aurelian,\u00a0TODERAS Ion.\u00a0Molybdenum-based feed supplement for bees. Brevet de inven\u021bie European EP4185594B1. Data public\u0103ri 2024-12-04.\u00a0https:\/\/patents.google.com\/patent\/EP4185594B1\/en?oq=EP4185594B1<\/a>.\u00a0https:\/\/worldwide.espacenet.com\/patent\/search?q=pn%3DEP4185594B1<\/a><\/li>\n<\/ol>\n

              Brevete de inven\u021bie na\u021bionale<\/strong><\/p>\n

                \n
              1. GULEA, A., GRAUR, V., GRAUR, I., \u0162APCOV, V., B\u0102LAN, G., LOZAN-T\u00ceR\u015eU, C. N-(biciclo[2,2,1]heptan-2-il)-2-[(piridin-2-il)metiliden]-hidrazin-1-carbotioamida, care manifest\u0103 activitate antimicotic\u0103 fa\u0163\u0103 de fungii din specia Candida albicans. 2026.04.30. Brevet de inven\u021bie MD nr.4936. Publicat BOPI 04\/2026. https:\/\/db.agepi.md\/Inventions\/details\/a%202024%200021<\/a><\/li>\n
              2. GULEA, Aurelian; \u021aAPCOV, Victor; GARBUZ, Olga; RUSNAC, Roman; P\u00ceNTEA, Aliona. Compu\u0219i coordinativi <\/a>nitrato-{N-[(2-metoxifenil)-2-(piridin-2-il- metiliden)-hidrazin-1-carbotioamido)]}cupru \u0219i nitrato-{N-[(4-metoxifenil)-2-(piridin-2-il-metiliden)-hidrazin-1-carbotioamido)]}cupru, care inhib\u0103 proliferarea celulelor cancerigene \/\/ Brevet de inven\u021bie MD nr.4948. Publicat \u00een BOPI 1\/2026. P.34-35. https:\/\/db.agepi.md\/Inventions\/details\/a%202024%200031<\/a><\/li>\n
              3. GULEA, Aurelian; \u021aAPCOV, Victor; GARBUZ, Olga; POIRIER, Donald; PAHON\u021aU, Elena-Mihaela.<\/a> N-(dimetilfenil)-2-[1-(piridin-2-il)etiliden]-hidrazin-1-carbotioamide \u00een calitate de inhibitori ai prolifer\u0103rii celulelor HepG2 ale cancerului la ficat \/\/ Brevet de inven\u021bie MD nr.4949. Publicat \u00een BOPI 1\/2026. P. 35. https:\/\/db.agepi.md\/Inventions\/details\/a%202024%200037<\/a><\/li>\n
              4. GARBUZ, O., GRAUR, V., \u0162APCOV, V., TODERA\u015e, I., GULEA, A. Clorura de tris[N-(prop-2-en-1-il)hidrazincarbotioamid]cobalt(III), care posed\u0103 propriet\u0103\u0163i de stimulator al statutului antioxidant total al hemolimfei albinelor Apis mellifera \u015fi larvelor acestora. Brevet de inven\u021bie MD 4905 din 31.05.2025. \u00a0https:\/\/db.agepi.md\/Inventions\/details\/a%202023%200014<\/a><\/li>\n
              5. GULEA, A., \u0162APCOV, V., ISTRATI, D., POIRIER, D. Utilizarea di(m-S)-bis{cloro-[N-(2,4-dimetilfenil)-N’-(piridin-2-ilmetiliden)carbamohidrazonotioat]cupru} tetrahidrat \u00een calitate de inhibitor al prolifer\u0103rii celulelor HepG2 ale cancerului la ficat. Brevet de inven\u021bie MD 4899 din 31.03.2025. https:\/\/db.agepi.md\/Inventions\/details\/a%202023%200021<\/a><\/li>\n
              6. GULEA, A., \u0162APCOV, V., POIRIER, D., LOZAN, V. Utilizarea di(\u00b5-S)-bis{cloro-[N-(fenil)-N’-(piridin-2-ilmetiliden)carbamohidrazonotioat][4-amino-N-(1,3-tiazol-2-il)benzensulfonamid]cupru} dihidrat \u00een calitate de inhibitor al activit\u0103\u0163ii enzimei 17b-HSD Tipul 1. Brevet de inven\u021bie MD 4903 din 31.05.2025. https:\/\/db.agepi.md\/Inventions\/details\/a%202023%200022<\/a><\/li>\n
              7. GARBUZ O., GRAUR V., \u021aAPCOV V., TODERA\u0218 I., GULEA A. Clorur\u0103 de tris[N-(prop-2-en-1-il)hidrazincarbotioamid]cobalt(III), care posed\u0103 propriet\u0103\u021bi de stimulator al statutului antioxidant total al hemolimfei albinelor Apis mellifera \u00a0\u0219i larvelor acestora. Brevet de inven\u021bie MD 4905. 2024 din 2024.10.31.\u00a0 https:\/\/www.db.agepi.md\/Inventions\/details\/a%202023%200014\/LinkTitluAcc<\/a><\/li>\n
              8. GULEA A., \u021aAPCOV V., POIRIER D., LOZAN V. Utilizarea di(m-S)-bis{cloro-[N-(fenil)-N\u2019-(piridin-2-il-metiliden)carbamohidrazonotioat][4-amino-N-(1,3-tia-zol-2-il)benzensulfonamid]cupru} dihidrat \u00een calitate de inhibitor al activit\u0103\u021bii enzimei 17b-HSD Tipul 1. Brevet de inven\u021bie MD 4903 din 2024.10.31.\u00a0 https:\/\/www.db.agepi.md\/Inventions\/details\/a%202023%200022\/LinkTitluAcc<\/a><\/li>\n
              9. GULEA Aurelian; CEBOTARI Diana; FLOQUET S\u00e9bastien; \u0162APCOV Victor; B\u0102LAN Greta; LOZAN-T\u00ceR\u015eU C. (m2-Bromo)-{m2-2,2′-[(5-ter\u0163-butil-2-oxido-1,3-fenilen)dimetaniliden]bis(N-metilhidrazin-1-carbotioamido)}-di-cupru(II), care manifest\u0103 activitate antimicotic\u0103 fa\u0163\u0103 de Candida albicans. Brevet de inven\u021bie MD 4886 din 2024.09.30. https:\/\/www.db.agepi.md\/Inventions\/details\/a%202022%200041\/LinkTitluElib<\/a><\/li>\n
              10. GULEA Aurelian; RUSNAC Roman; \u0162APCOV Victor; B\u0102LAN Greta; LOZAN-T\u00ceR\u015eU Carolina; CEBAN Emil. Hidratul de bis{N-ciclohexil-N’-[(piridin-2-il)metiliden]carbamohidrazontioato}nichel, care manifest\u0103 activitate bacteriostatic\u0103 fa\u0163\u0103 de bacteriile din specia Streptococcus pneumoniae. Brevet de inven\u021bie MD 4883 din 2024.08.31. https:\/\/www.db.agepi.md\/Inventions\/details\/a%202022%200028\/LinkTitluElib<\/a><\/li>\n
              11. GULEA, A.; \u021aAPCOV, V.; ISTRATI, D.; POIRIER, D. Utilizarea di(m-S)-bis{cloro-[N-(2,4-dimetilfenil)-N\u2019-(piridin-2-ilmetiliden)carbamohidrazonotioat]cupru} tetrahidrat \u00een calitate de inhibitor al prolifer\u0103rii celulelor HepG2 ale cancerului la ficat. Brevet de inven\u021bie\u00a0 MD 4899 din 2024.08.31. https:\/\/www.db.agepi.md\/Inventions\/details\/a%202023%200021\/LinkTitluAcc<\/a><\/li>\n
              12. GULEA, A., GRAUR, V., BALAN, G., \u021aAPCOV, V., TODERA\u0218, I., LOZAN, V. Nitrato- (N-(prop-2-en-1-il)-N , -(1-(piridin-2-il)-etiliden)carbamohidrazontio)cupru, care manifest\u0103 activitate antimicrobian\u0103 fa\u021b\u0103 de bacteriile din specia Streptococcus pneumoniae. Brevet de inventie, MD4842 C1 din 2023.01.31, BOPI nr. 1\/2023.<\/li>\n<\/ol>\n<\/div>\n
                \n
                  \n
                1. PROIECT \u201dTRANSFER TEHNOLOGIC 2026-2028\u201d<\/strong><\/b>\n
                    \n
                  1. 26.80015.5107.01TT. Transfer tehnologic pentru producerea b\u0103uturilor cu noi forme a complec\u0219ilor.<\/a>\u0441helatici ai biometalelor pe baz\u0103 de siropuri naturali.<\/a>
                    \nPerioada de realizare: 2026-2028
                    \nConduc\u0103tor: Academician, dr. habilitat, prof. univ. Aurelian GULEA<\/li>\n<\/ol>\n

                    PROIECTE\u00a0BILATERAL\u00a0MOLDO-TURC\u00a0 PENTRU ANII 2026-2028<\/strong><\/p>\n

                      \n
                    1. 26.80013.8007.02MDTR.\u00a0Evaluarea mecanismelor de moarte celular\u0103 imunogen\u0103 mediate de cupru \u0219i mangan, combinate cu curcumina, pentru imunoterapia cancerului mamar triplu negativ<\/a>
                      \nPerioada de realizare: 2026-2028
                      \nConduc\u0103torul proiectului: Academician Aurelian GULEA<\/li>\n<\/ol>\n

                      SUBPROGRAM\u00a0DE CERCETARE<\/strong><\/b><\/p>\n

                        \n
                      1. Sinteza \u0219i studiul materialelor noi \u00een baza combina\u021biilor complexe cu liganzi polifunc\u021bionali \u0219i cu propriet\u0103\u021bi utile \u00een medicin\u0103, biologie \u0219i tehnic\u0103 (SSMCCLP)\u00a0<\/a>(cod: 010602)<\/a>
                        \nPerioada de realizare: 2024-2027
                        \nConduc\u0103tor:\u00a0                        Dr. habilitat, conf. cerc. Vasile<\/a>\u00a0LOZAN<\/a><\/li>\n<\/ol>\n

                        PROIECT\u00a0\u201eTINERI CERCET\u0102TORI PENTRU ANII 2024-2025\u201d\u00a0<\/strong><\/b><\/p>\n

                          \n
                        1. 24.80012.5007.14TC. Molecule bioactive cu poten\u021bial de aplicare \u00een calitate de agen\u021bi antimicrobieni \u0219i antifungici ce con\u021bin fragmente din compu\u0219i naturali sau medicamente<\/a>
                          \nPerioada de realizare: 2024-2025
                          \nConduc\u0103tor:\u00a0                          Dr. Vasilii GRAUR<\/a><\/li>\n<\/ol>\n

                          PROIECT\u00a0\u201eSTIMULAREA EXCELEN\u021aEI \u00ceN CERCETARE PENTRU ANII 2024-2025\u201d<\/strong><\/b><\/p>\n

                            \n
                          1. 24.80012.8007.01SE. Sinteza \u0219i studiul noilor inhibitori autohtoni ai celulelor de cancer cu luarea \u00een considerare a activit\u0103\u021bii antiproliferative \u0219i a toxicit\u0103\u021bii<\/a>
                            \nPerioada de realizare: 2024-2025
                            \nConduc\u0103tor:\u00a0                            Academician, dr. habilitat, prof. Aurelian GULEA<\/a><\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n
                            \n
                            <\/div>\n
                            \n
                            <\/div>\n<\/div>\n<\/div><\/div><\/div>\n

                             <\/p>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

                            \u0218eful laboratorului academician, dr. habilitat, prof. univ.\u00a0Aurelian GULEA Birou: Telefon: Email: aurelian.gulea @ usm.md Domenii de cercetare Direc\u021biile actuale de cercetare ale laboratorului\u00a0sunt orientate spre biomedicin\u0103 \u0219i materiale avansate\/inovative. Activitatea principal\u0103 se concentreaz\u0103 pe designul, sinteza dirijat\u0103 \u0219i caracterizarea de noi combina\u021bii coordinative (ale biometalelor) cu liganzi polifunc\u021bionali care con\u021bin seturi de atomi NNS, SNO, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-81","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/idcc.usm.md\/index.php?rest_route=\/wp\/v2\/pages\/81","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idcc.usm.md\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idcc.usm.md\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idcc.usm.md\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idcc.usm.md\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=81"}],"version-history":[{"count":13,"href":"https:\/\/idcc.usm.md\/index.php?rest_route=\/wp\/v2\/pages\/81\/revisions"}],"predecessor-version":[{"id":847,"href":"https:\/\/idcc.usm.md\/index.php?rest_route=\/wp\/v2\/pages\/81\/revisions\/847"}],"wp:attachment":[{"href":"https:\/\/idcc.usm.md\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=81"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}